Publications

Main content

2017

Fast NMR-Based Determination of the 3D Structure of the Binding Site of Protein–Ligand Complexes with Weak Affinity Binders.
Marielle A. Wälti, Roland Riek, and Julien Orts
Angewandte Chemie - International Edition in English, (2017) Weinheim: Wiley.
Quenched hydrogen-deuterium exchange NMR of a disease-relevant Aß(1-42) amyloid polymorph.
Marielle A. Wälti, Julien Orts, and Roland Riek
Plos One, (2017) San Francisco, CA: Public Library of Science.
α-Synuclein Lipoprotein Nanoparticles.
Cédric Eichmann, Stefan Bibow, and Roland Riek
Nanotechnology Reviews, (2017) Berlin: De Gruyter.
High-Density Lipoprotein-Like Particle Formation of Synuclein Variants.
Cédric Eichmann, Pratibha Kumari, and Roland Riek
FEBS Letters, (2017) Chichester: Wiley.
Micelles, Bicelles, and Nanodiscs: Comparing the Impact of Membrane Mimetics on Membrane Protein Backbone Dynamics.
Lukas Frey, Nils-Alexander Lakomek, Roland Riek, and Stefan Bibow
Angewandte Chemie. International edition in English, (2017) Weinheim: Wiley.
Amyloid Fibril Polymorphism: Almost Identical on the Atomic Level, Mesoscopically Very Different.
Carolin Seuring, Joeri Verasdonck, Philippe Ringler, Riccardo Cadalbert, Henning Stahlberg, Anja Böckmann, Beat H. Meier, and Roland Riek
The Journal of Physical Chemistry B, (2017) Washington, DC: American Chemical Society.
Structures of the first extracellular domain of CRF receptors.
Viviane Zelenay, Marilyn Perrin, and Roland Riek
Current Molecular Pharmacology, (2017) Sharjah: Bentham.

2016

More than a Rumor Spreads in Parkinson's Disease.
Natalia C. Prymaczok, Roland Riek, and Juan Gerez
Frontiers in Human Neuroscience, (2016) Lausanne: Frontiers Research Foundation.
The activities of amyloids from a structural perspective.
Roland Riek, and David S. Eisenberg
Nature, (2016) London: Nature Publ. Group.
Solid-state NMR sequential assignment of an Amyloid-β(1–42) fibril polymorph.
Francesco Ravotti, Marielle A. Wälti, Peter Güntert, Roland Riek, Anja Böckmann, and Beat H. Meier
Biomolecular NMR Assignments, (2016) Dordrecht: Springer.
Solid-state NMR sequential assignment of the β-endorphin peptide in its amyloid form.
Carolin Seuring, Julia Gath, Joeri Verasdonck, Riccardo Cadalbert, Jean Rivier, Anja Böckmann, Beat H. Meier, and Roland Riek
Biomolecular NMR Assignments, (2016) Dordrecht: Springer.
Amyloid Aggregates Arise from Amino Acid Condensations under Prebiotic Conditions.
Jason Greenwald, Michael P. Friedmann, and Roland Riek
Angewandte Chemie - International Edition, (2016) Weinheim: Wiley.
The Dynamic Basis for Signal Propagation in Human Pin1-WW.
Simon Olsson, Dean Strotz, Beat Vögeli, Roland Riek, and Andrea Cavalli
Structure, (2016) Cambridge, MA: Cell Press.
The Neurite Outgrowth Inhibitory Nogo-A-Δ20 Region Is an Intrinsically Disordered Segment Harbouring Three Stretches with Helical Propensity.
Viviane Zelenay, Michael E. Arzt, Stefan Bibow, Martin E. Schwab, and Roland Riek
PloS One, (2016) San Francisco, CA: Public Library of Science.
Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril.
Marielle A. Wälti, Francesco Ravotti, Hiromi Arai, Charles G. Glabe, Joseph S. Wall, Anja Böckmann, Peter Güntert, Beat H. Meier, and Roland Riek
Proceedings of the National Academy of Sciences of the United States of America, (2016) Washington, DC: National Academy of Sciences.
Direct Investigation of Slow Correlated Dynamics in Proteins via Dipolar Interactions.
R. Bryn Fenwick, Charles D. Schwieters, and Beat Vögeli
Journal of the American Chemical Society, (2016) Washington, DC: American Chemical Society.
Ligand binding to the PDZ domains of postsynaptic density protein 95.
Angelo Toto, Søren W. Pedersen, O.A. Karlsson, Griffin E. Moran, Eva Andersson, Celestine N. Chi, Kristian Strømgaard, Stefano Gianni, and Per Jemth
Protein Engineering, Design & Selection, (2016) Oxford: Oxford University Press.
NMR-Based Determination of the 3D Structure of the Ligand-Protein Interaction Site without Protein Resonance Assignment.
Julien Orts, Marielle A. Wälti, May Marsh, Laura Vera, Alvar D. Gossert, Peter Güntert, and Roland Riek
Journal of the American Chemical Society, (2016) Washington, DC: American Chemical Society.
Enzyme Selectivity Fine-Tuned through Dynamic Control of a Loop.
Beat Vögeli, Stefan Bibow, and Celestine N. Chi
Angewandte Chemie. International Edition in English, (2016) Weinheim: Wiley.
Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I.
Stefan Bibow, Yevhen Polyhach, Cédric Eichmann, Celestine N. Chi, Julia Kowal, Stefan Albiez, Robert A. McLeod, Henning Stahlberg, Gunnar Jeschke, Peter Güntert, and Roland Riek
Nature. Structural and Molecular Biology, (2016) New York, NY: Nature Publ. Group.
Preparation and characterization of stable α-synuclein lipoprotein particles.
Cedric Eichmann, Silvia Campioni, Julia Kowal, Innokentiy Maslennikov, Juan Gerez, Xiaoxia Liu, Joeri Verasdonck, Nadezhda Nespovitaya, Senyon Choe, Beat H. Meier, Paola Picotti, Josep Rizo, Henning Stahlberg, and Roland Riek
The journal of biological chemistry, (2016) Bethesda, MD, USA: American Society for Biochemistry and Molecular Biology Inc..
S-Sulfhydration of the Catalytic Cysteine in the Rhodanese Domain of YgaP is Complex Dynamic Process.
Cédric Eichmann, Christos Tzitzilonis, Witek Kwiatkowski, and Roland Riek
Matters, (2016) Zürich: ScienceMatters AG.
S-Nitrosylation Induces Structural and Dynamical Changes in a Rhodanese Family Protein.
Cédric Eichmann, Christos Tzitzilonis, Tomohiro Nakamura, Witek Kwiatkowski, Innokentiy Maslennikov, Senyon Choe, Stuart A. Lipton, and Roland Riek
Journal of Molecular Biology, (2016) Amsterdam: Elsevier.
Dynamic assembly and disassembly of functional β-endorphin amyloid fibrils.
Nadezhda Nespovitaya, Julia Gath, Konstantin Barylyuk, Carolin Seuring, Beat H. Meier, and Roland Riek
Journal of the American Chemical Society, (2016) Washington, DC: American Chemical Society.
The HET-s/s prion motif in the control of programmed cell death.
Roland Riek, and Sven J. Saupe
Cold Spring Harbor Perspectives in Biology, (2016) Woodbury, NY: Cold Spring Harbor Laboratory Press.
The Three-Dimensional Structures of Amyloids.
Roland Riek
Cold Spring Harbor Perspectives in Biology, (2016) Woodbury, NY: Cold Spring Harbor Laboratory Press.
The Exact NOE as an Alternative in Ensemble Structure Determination.
Beat Vögeli, Simon Olsson, Peter Güntert, and Roland Riek
Biophysical Journal, (2016) Cambridge, MA: Cell Press.

2015

Compiled data set of exact NOE distance limits, residual dipolar couplings and scalar couplings for the protein GB3.
Beat Vögeli, Simon Olsson, Roland Riek, and Peter Güntert
Data in Brief, (2015) Amsterdam: Elsevier BV.
Uncovering the Mechanism of Aggregation of Human Transthyretin.
Lorena Saelices, Lisa M. Johnson, Wilson Y. Liang, Michael R. Sawaya, Duilio Cascio, Piotr Ruchala, Julian Whitelegge, Lin Jiang, Roland Riek, and David S. Eisenberg
Journal of Biological Chemistry, (2015) Bethesda, MD: The American Society for Biochemistry and Molecular Biology.
The experimental accuracy of the uni-directional exact NOE.
Dean Strotz, Julien Orts, Martina Minges, and Beat Vögeli
Journal of Magnetic Resonance, (2015) Amsterdam: Elsevier.
Complementarity and congruence between exact NOEs and traditional NMR probes for spatial decoding of protein dynamics.
Beat Vögeli, Simon Olsson, Roland Riek, and Peter Güntert
Journal of Structural Biology, (2015) Amsterdam: Elsevier.
α-Synuclein Insertion into Supported Lipid Bilayers As Seen by in Situ X-ray Reflectivity.
Hendrik Hähl, Isabelle Möller, Irena Kiesel, Silvia Campioni, Roland Riek, Dorinel Verdes, and Stefan Seeger
ACS Chemical Neuroscience, (2015) Washington, DC: American Chemical Society.
Toxicity of Eosinophil MBP Is Repressed by Intracellular Crystallization and Promoted by Extracellular Aggregation.
Alice Soragni, Shida Yousefi, Christina Stoeckle, Angela B. Soriaga, Michael R. Sawaya, Evelyne Kozlowski, Ines Schmid, Susanne Radonjic-Hoesli, Sebastien Boutet, Garth J. Williams, Marc Messerschmidt, M. Marvin Seibert, Duilio Cascio, Nadia A. Zatsepin, Manfred Burghammer, Christian Riekel, Jacques-Philippe Colletier, Roland Riek, David S. Eisenberg, and Hans-Uwe Simon
Molecular Cell, (2015) Cambridge, MA: Cell Press.
Solution NMR studies of recombinant Aβ(1-42): from the presence of a micellar entity to residual β-sheet structure in the soluble species.
Marielle A. Walti, Julien Orts, Beat Vögeli, Silvia Campioni, and Roland Riek
ChemBioChem, (2015) Weinheim: Wiley.
Extending the eNOE data set of large proteins by evaluation of NOEs with unresolved diagonals.
Celestine N. Chi, Dean Strotz, Roland Riek, and Beat Voegeli
Journal of Biomolecular Nmr, (2015) Springer: Berlin.
A Structural Ensemble for the Enzyme Cyclophilin Reveals an Orchestrated Mode of Action at Atomic Resolution.
Celestine N. Chi, Beat R. Vögeli, Stefan Bibow, Dean Strotz, Julien Orts, Peter Güntert, and Roland Riek
Angewandte Chemie - International edition, (2015) Weinheim: Wiley.
Towards Prebiotic Catalytic Amyloids Using High Throughput Screening.
Michael P. Friedmann, Vladimir Torbeev, Viviane Zelenay, Alexander Sobol, Jason Greenwald, and Roland Riek
PLoS one, (2015) Lawrence, Kan.: Public Library of Science.
Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation.
Dhiman Ghosh, Pradeep K. Singh, Shruti Sahay, Narendra N. Jha, Reeba S. Jacob, Shamik Sen, Ashutosh Kumar, Roland Riek, and Samir K. Maji
Scientific Reports, (2015) London: Nature Publishing Group.
Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus.
O. Andreas Karlsson, Juan Ramirez, Daniel Öberg, Tony Malmqvist, Åke Engström, Maria Friberg, Celestine N. Chi, Mikael Widersten, Gilles Travé, Mikael T.I. Nilsson, and Per Jemth
Scientific Reports, (2015) London: Nature Publishing Group.

2014

Intermolecular Detergent−Membrane Protein NOEs for the Characterization of the Dynamics of Membrane Protein−Detergent Complexes.
Cédric Eichmann, Julien Orts, Christos Tzitzilonis, Beat Vögeli, Sean Smrt, Justin Lorieau, and Roland Riek
The journal of physical chemistry. B, (2014) Washington, DC: American Chemical Society.
Probabilistic Determination of Native State Ensembles of Proteins.
Simon Olsson, Beat R. Vögeli, Andrea Cavalli, Wouter Boomsma, Jesper Ferkinghoff-Borg, Kresten Lindorff-Larsen, and Thomas Hamelryck
Journal of chemical theory and computation, (2014) Washington, DC, USA: American Chemical Society.
Heterodimerization of p45-p75 Modulates p75 Signaling. Structural Basis and Mechanism of Action.
Marçal Vilar, Tsung-Chang Sung, Zhijiang Chen Chen, Irmina Garcia-Carpio, Eva M. Fernandez, Jiqing Q. Xu, Roland Riek, and Kuo-Fen Lee
PLoS biology, (2014) Lawrence, KS: Public Library of Science.
Measuring membrane protein bond orientations in nanodiscs via residual dipolar couplings.
Stefan Bibow, Marta G. Carneiro, T. Michael Sabo, Claudia Schwiegk, Stefan Becker, Roland Riek, and Donghan Lee
Protein science, (2014) Chichester: Wiley-Blackwell.
The production of recombinant 15N, 13C-labelled somatostatin 14 for NMR spectroscopy.
Nadezhda Nespovitaya, Konstantin Barylyuk, Cédric Eichmann, Renato Zenobi, and Roland Riek
Protein expression & purification, (2014) Amsterdam: Elsevier.
A Derivation of a Microscopic Entropy and Time Irreversibility From the Discreteness of Time.
Roland Riek
Entropy, (2014) S.l.: MDPI.
Contribution of Specific Residues of the beta-Solenoid Fold to HET-s Prion Function, Amyloid Structure and Stability.
Asen Y. Daskalov, Matthias Gantner, Marielle A. Wälti, Thierry Schmidlin, Celestine Chi, Christian Wasmer, Anne K. Schütz, Johanna Ceschin, Corinne Clavé, Sandra Cescau, Beat H. Meier, Roland Riek, and Sven J. Saupe
Plos pathogens, (2014) San Francisco, CA: Public Library of Science.
Towards a true protein movie. A perspective on the potential impact of the ensemble-based structure determination using exact NOEs.
Beat Vögeli, Julien Orts, Dean Strotz, Celestine Chi, Martina Minges, Marielle Aulikki Wälti, Peter Güntert, and Roland Riek
Journal of magnetic resonance, (2014) Amsterdam: Elsevier.
The nuclear Overhauser effect from a quantitative perspective.
Beat Vögeli
Progress in nuclear magnetic resonance spectroscopy, (2014) Amsterdam: Elsevier.
The Structure of Mouse Cytomegalovirus m04 Protein Obtained from Sparse NMR Data Reveals a Conserved Fold of the m02-m06 Viral Immune Modulator Family.
Nikolaos G. Sgourakis, Kannan Natarajan, Jinfa Ying, Beat Vögeli, Lisa F. Boyd, David H. Margulies, and Ad Bax
Structure, (2014) Cambridge, MA: Cell Press.
The Presence of an Air-Water Interface Affects Formation and Elongation of α-Synuclein Fibrils.
Silvia Campioni, Guillaume Carret, Sophia Jordens, Lucrece Nicoud, Raffaele Mezzenga, and Roland Riek
Journal of the American Chemical Society, (2014) Washington, DC: American Chemical Society.
Solution NMR Structure and Functional Analysis of the Integral Membrane Protein YgaP from Escherichia coli.
Cédric Eichmann, Christos Tzitzilonis, Enrica Bordignon, Innokentiy Maslennikov, Senyon Choe, and Roland Riek
The journal of biological chemistry, (2014) Bethesda, MD: The American Society for Biochemistry and Molecular Biology.
Expression and Functional Characterization of Membrane-Integrated Mammalian Corticotropin Releasing Factor Receptors 1 and 2 in Escherichia coli.
Roberto Jappelli, Marilyn H. Perrin, Kathy A. Lewis, Joan M. Vaughan, Christos Tzitzilonis, Jean E. Rivier, Wylie W. Vale, and Roland Riek
Plos One, (2014) Lawrence, Kan.: Public Library of Science.
Accumulation of oligomer-prone alpha-synuclein exacerbates synaptic and neuronal degeneration in vivo.
E. Rockenstein, S. Nuber, C. R. Overk, K. Ubhi, M. Mante, C. Patrick, A. Adame, M. Trejo-Morales, J. Gerez, P. Picotti, P.H. Jensen, S. Campioni, Roland Riek, J. Winkler, F. H. Gage, B. Winner, and E. Masliah
Brain, (2014) Oxford, UK: Oxford University Press.

2013

Stereospecific assignments in proteins using exact NOEs.
Julien Orts, Beat Vögeli, Roland Riek, and Peter Güntert
Journal of biomolecular NMR, (2013) Berlin: Springer.
{alpha}-Synuclein oligomers impair neuronal microtubule-kinesin interplay.
Iryna Prots, Vanesa Veber, Stefanie Brey, Silvia Campioni, Katrin Buder, Roland Riek, Konrad J. Böhm, and Beate Winner
The journal of biological chemistry, (2013) Bethesda, MD: The American Society for Biochemistry and Molecular Biology.
Superresolution Imaging of Amyloid Fibrils with Binding-Activated Probes.
Jonas Ries, Vinod Udayar, Alice Soragni, Simone Hornemann, K. Peter R. Nilsson, Roland Riek, Christoph Hock, Helge Ewers, Adriano A. Aguzzi, and Lawrence Rajendran
ACS chemical neuroscience, (2013) Washington, DC: American Chemical Society.
On-Surface Aggregation of alpha-Synuclein at Nanomolar Concentrations Results in Two Distinct Growth Mechanisms.
Michael Rabe, Alice Soragni, Nicholas P. Reynolds, Dorinel Verdes, Ennio Liverani, Roland Riek, and Stefan Seeger
ACS chemical neuroscience, (2013) American Chemical Society.
Multiple-state ensemble structure determination from eNOE spectroscopy.
Beat Vogeli, Peter Güntert, and Roland Riek
Molecular Physics, (2013) London: Taylor & Francis.
Polychromatic frequency encoding of indirect dimensions in NMR Spectroscopy.
Cédric Eichmann, Alexander Sobol, Konstantin Pervushin, and Roland Riek
Molecular physics, (2013) London: Taylor & Francis.
The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.
T. Sonati, R.R. Reimann, J. Falsig, P. K. Baral, T. O'Connor, S. Hornemann, S. Yaganoglu, B. Li, U.S. Herrmann, B. Wieland, M. Swayampakula, M.H. Rahman, D. Das, N. Kav, Roland Riek, P.P. Liberski, M.N.G. James, and A. Aguzzi
Nature, (2013) London: Nature Publ. Group.
P45 Forms a Complex with FADD and Promotes Neuronal Cell Survival Following Spinal Cord Injury.
T.C. Sung, Z.J. Chen, S. Thuret, M. Vilar, F.H. Gage, Roland Riek, and K.F. Lee
PLoS ONE, (2013) San Francisco, CA, USA: Public Library of Science.
Detergent/Nanodisc Screening for High-Resolution NMR Studies of an Integral Membrane Protein Containing a Cytoplasmic Domain.
Christos Tzitzilonis, Cédric Eichmann, Innokentiy Maslennikov, Senyon Choe, and Roland Riek
PLoS ONE, (2013) Lawrence, Kan.: Public Library of Science.
Full relaxation matrix analysis of apparent cross-correlated relaxation rates in four-spin systems.
Beat Vögeli
Journal of magnetic resonance, (2013) Amsterdam: Elsevier.

2012

Salt Anions Promote the Conversion of HypF-N into Amyloid-Like Oligomers and Modulate the Structure of the Oligomers and the Monomeric Precursor State.
Silvia Campioni, Benedetta Mannini, Jorge P. López-Alonso, Irina N. Shalova, Amanda Penco, Estefania Mulvihill, Douglas V. Laurents, Annalisa Relini, and Fabrizio Chiti
Journal of molecular biology, (2012) Amsterdam: Elsevier.
Relaxation Matrix Analysis of Spin Diffusion for the NMR Structure Calculation with eNOEs.
Julien Orts, Beat Vögeli, and Roland Riek
Journal of chemical theory and computation, (2012) Washington, DC: American Chemical Society.
Spatial elucidation of motion in proteins by ensemble-based structure calculation using exact NOEs.
Beat Vögeli, Sina Kazemi, Peter Güntert, and Roland Riek
Nature structural & molecular biology, (2012) New York, N.Y.: Nature Publ. Group.
Discrete Three-dimensional Representation of Macromolecular Motion from eNOE-based Ensemble Calculation.
Beat Vögeli, Julien Orts, Dean Strotz, Peter Güntert, and Roland Riek
Chimia, (2012) Bern: Swiss Chemical Society.
Amyloids seen by solid-state NMR: Atomic-resolution structure, dynamics, and characterization of the pharmacophore.
Beat H. Meier, Anja Böckmann, Matthias Ernst, Roland Melki, Roland Riek, L. Bousset, Julia Gath, Birgit Habenstein, M. Huber, N. Lickgei, Francesco Ravotti, Andri Schütz, Cornelia Seuring, and Christian Wasmer
The FEBS journal, (2012) Oxford: Wiley-Blackwell.
On the Possible Amyloid Origin of Protein Folds.
Jason Greenwald, and Roland Riek
Journal of Molecular Biology, (2012) Amsterdam: Elsevier.
Facile backbone structure determination of human membrane proteins by NMR spectroscopy.
Christian Klammt, Innokentiy Maslennikov, Monika Bayrhuber, Cédric Eichmann, Navratna Vajpai, Ellis J. C. Chiu, Katherine Y. Blain, Luis Esquivies, June H. J. Kwon, Bartosz Balana, Ursula Pieper, Andrej Sali, Paul A. Slesinger, Witek Kwiatkowski, Roland Riek, and Senyon Choe
Nature Methods, (2012) New York, NY: Nature Publ. Group.
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers.
Benedetta Mannini, et al., and Silvia Campioni
Proceedings of the National Academy of Sciences of the United States of America, (2012) Washington, D.C.: National Academy of Sciences.
Editorial.
Matthias Ernst, and Roland Riek
Chimia, (2012) Bern: Swiss Chemical Society.
Localization of HET-S to the Cell Periphery, Not to [Het-s] Aggregates, Is Associated with [Het-s]–HET-S Toxicity.
Vidhu Mathur, Caroline Seuring, Roland Riek, Sven J. Saupe, and Susan W. Liebman
Molecular and cellular biology, (2012) Washington, D.C.: American Society for Microbiology.
The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility.
Carolin Seuring, Jason Greenwald, Christian Wasmer, Roger Wepf, Sven J. Saupe, Beat H. Meier, and Roland Riek
PLoS biology, (2012) Lawrence, KS: Public Library of Science.
Structural Studies of Amyloids by Quenched Hydrogen–Deuterium Exchange by NMR.
Marçal Vilar, Lei Wang, and Roland Riek
Methods in molecular biology, (2012) New York: Humana Press.

2011

A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer’s Disease.
Qi Chen, Marguerite Prior, Richard Dargusch, Amanda Roberts, Roland Riek, Cédric Eichmann, Chandramouli Chiruta, Tatsuhiro Akaishi, Kazuho Abe, Pamela Maher, and David Schubert
PLoS ONE, (2011) Lawrence, Kan: Public Library of Science.
A Receptor-based Switch that Regulates Anthrax Toxin Pore Formation.
Rosemarie M. Pilpa, Monika Bayrhuber, John M. Marlett, Roland Riek, and John A.T. Young
PLoS pathogens, (2011) Lawrence, KS: Public Library of Science.
How uniform is the peptide plane geometry? A high-accuracy NMR study of dipolar C(alpha)-C '/H(N)-N cross-correlated relaxation.
Beat Vögeli
Journal of biomolecular NMR, (2011) Berlin: Springer.
Temperature Dependence of H-1(N)-H-1(N) Distances in Ubiquitin As Studied by Exact Measurements of NOEs.
Dominik Leitz, Beat Vögeli, Jason Greenwald, and Roland Riek
The journal of physical chemistry. B, (2011) Washington, DC: American Chemical Society.
Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator. Implications for Catalysis and Hyperactivation.
Sabine Kuettel, Jason Greenwald, Dirk Kostrewa, Shaheen Ahmed, Leonardo Scapozza, and Remo Perozzo
PLoS neglected tropical diseases, (2011) Lawrence, Kan.: PLoS.
Very simple combination of TROSY, CRINEPT and multiple quantum coherence for signal enhancement in an HN(CO)CA experiment for large proteins.
Monika Bayrhuber, and Roland Riek
Journal of magnetic resonance, (2011) Amsterdam: Elsevier.
In vivo demonstration that alpha-synuclein oligomers are toxic.
Beate Winner, Roberto Jappelli, Samir K. Maji, Paula A. Desplats, Leah Boyer, Stefan Aigner, Claudia Hetzer, Thomas Loher, Marcal Vilar, Silvia Campionic, Christos Tzitzilonis, Alice Soragni, Sebastian Jessberger, Helena Mira, Antonella Consiglio, Emiley Pham, Eliezer Masliah, Fred H. Gage, and Roland Riek
Proceedings of the National Academy of Sciences of the United States of America, (2011) Washington, D.C.: National Academy of Sciences.
A Receptor-based Switch that Regulates Anthrax Toxin Pore Formation.
Rosemarie M. Pilpa, Monika Bayrhuber, John M. Marlett, Roland Riek, and John A.T. Young
PLoS pathogens, (2011) Lawrence, Kan.: Public Library of Science.
Mechanism of Membrane Interaction and Disruption by alpha-Synuclein.
Nicholas P. Reynolds, Alice Soragni, Michael Rabe, Dorinel Verdes, Ennio Liverani, Stephan Handschin, Roland Riek, and Stefan Seeger
Journal of the American Chemical Society, (2011) Washington, DC: American Chemical Society.

2010

NMR Structure of the First Extracellular Domain of Corticotropin-releasing Factor Receptor 1 (ECD1-CRF-R1) Complexed with a High Affinity Agonist.
Christy Rani R. Grace, Marilyn H. Perrin, Jozsef Gulyas, Jean E. Rivier, Wylie W. Vale, and Roland Riek
The journal of biological chemistry, (2010) Bethesda, MD: The American Society for Biochemistry and Molecular Biology.
Biology of Amyloid. Structure, Function, and Regulation.
Jason Greenwald, and Roland Riek
Structure, (2010) Cambridge, MA: Elsevier.
Amyloid. Units of Activity.
Carolin Buhtz, and Roland Riek
Nachrichten aus der Chemie, (2010) Frankfurt a. M.: Gesellschaft Deutscher Chemiker.
The Propensity of -Aminoisobutyric Acid (=2-Methylalanine; Aib) to Induce Helical Secondary Structure in an -Heptapeptide. A Computational Study.
Dongqi Wang, Michael Friedmann, Zrinka Gattin, Bernhard Jaun, and Wilfred F. van Gunsteren
Helvetica chimica acta, (2010) Zürich: Verlag Helvetica Chimica Acta.
Transnitrosylation of XIAP Regulates Caspase-Dependent Neuronal Cell Death.
Tomohiro Nakamura, Lei Wang, Catherine C.L. Wong, Fiona L. Scott, Brendan P. Eckelman, Xuemei Han, Christos Tzitzilonis, Fanjun Meng, Zezong Gu, Emily A. Holland, Arjay T. Clemente, Shu-ichi Okamoto, Guy S. Salvesen, Roland Riek, Yates John R., and Stuart A. Lipton
Molecular cell, (2010) Cambridge, MA: Cell Press; Elsevier.
Comprehensive description of NMR cross-correlated relaxation under anisotropic molecular tumbling and correlated local dynamics on all time scales.
Beat Vögeli
The journal of chemical physics, (2010) Melville, NY: American Institute of Physics.
The Mechanism of Prion Inhibition by HET-S.
Jason Greenwald, Carolin Buhtz, Christiane Ritter, Witek Kwiatkowski, Senyon Choe, Marie-Lise Maddelein, Frederique Ness, Sandra Cescau, Alice Soragni, Dominik Leitz, Sven J. Saupe, and Roland Riek
Molecular cell, (2010) Cambridge, MA: Cell Press.
Cotranslational structure acquisition of nascent polypeptides monitored by NMR spectroscopy.
Cédric Eichmann, Steffen Preissler, Roland Riek, and Elke Deuerling
Proceedings of the National Academy of Sciences of the United States of America, (2010) Washington, D.C.: National Academy of Sciences.
Identifying the amylome, proteins capable of forming amyloid-like fibrils.
Lukasz Goldschmidt, Poh K. Teng, Roland Riek, and David Eisenberg
Proceedings of the National Academy of Sciences of the United States of America : PNAS, (2010) Washington, D.C.: National Academy of Science.
Protocols for the Sequential Solid-State NMR Spectroscopic Assignment of a Uniformly Labeled 25 kDa Protein. HET-s(1-227).
Anne Schuetz, Christian Wasmer, Birgit Habenstein, René Verel, Jason Greenwald, Roland Riek, Anja Boeckmann, and Beat H. Meier
ChemBioChem, (2010) Weinheim: Wiley.
Quantitative determination of NOE rates in perdeuterated and protonated proteins. Practical and theoretical aspects.
Beat Vögeli, Michael Friedmann, Dominik Leitz, Alexander Sobol, and Roland Riek
Journal of magnetic resonance, (2010) Amsterdam: Elsevier.
Side chain. Backbone projections in aromatic and ASX residues from NMR cross-correlated relaxation.
Beat Vögeli, and Roland Riek
Journal of biomolecular NMR, (2010) Berlin: Springer.
Multidimensional Structure Activity Relationship of a Protein in Its Aggregated States.
Lei Wang, David Schubert, Michael R. Sawaya, David Eisenberg, and Roland Riek
Angewandte Chemie. International edition in English, (2010) Weinheim: Wiley.

2009

The Molecular Organization of the Fungal Prion HET-s in Its Amyloid Form.
Christian Wasmer, Anne Schütz, Antoine Loquet, Carolin Buhtz, Jason Greenwald, Roland Riek, Ania Böckmann, and Beat H. Meier
Journal of molecular biology, (2009) Amsterdam: Elsevier.
Structure-activity relationship of amyloid fibrils.
Samir K. Maji, Lei Wang, Jason Greenwald, and Roland Riek
FEBS letters : the journal for rapid publication of short reports in molecular biosciences, (2009) Amsterdam: Elsevier.
Narrowing SWNT diameter distribution using size-separated ferritin-based Fe catalysts.
Lukas Durrer, Jason Greenwald, Thomas Helbling, Matthias Muoth, Roland Riek, and Christofer Hierold
Nanotechnology, (2009) Bristol: Institute of Physics.
Mistic. Cellular localization, solution behavior, polymerization, and fibril formation.
Hay Dvir, Matthew E. Lundberg, Samir K. Maji, Roland Riek, and Senyon Choe
Protein science, (2009) Chichester: Wiley.
Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues.
Judit Erchegyi, Renzo Cescato, Christy Rani R. Grace, Beatrice Waser, Véronique Piccand, Daniel Hoyer, Roland Riek, Jean E. Rivier, and Jean Claude Reubi
Journal of medicinal chemistry, (2009) Washington, DC: American Chemical Society.
FpvA bound to non-cognate pyoverdines. Molecular basis of siderophore recognition by an iron transporter.
Jason Greenwald, Mirella Nader, Hervé Celia, Christelle Gruffaz, Valérie Geoffroy, Jean-Marie Meyer, Isabelle J. Schalk, and Franc Pattus
Molecular microbiology, (2009) Oxford: Wiley-Blackwell.
Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules.
Samir K. Maji, Marilyn H. Perrin, Michael R. Sawaya, Sebastian Jessberger, Krishna Vadodaria, Robert A. Rissman, Praful S. Singru, K. Peter R. Nilsson, Rosalyn Simon, David Schubert, David Eisenberg, Jean Rivier, Paul Sawchenko, Wylie Vale, and Roland Riek
Science, (2009) Washington, D.C.: American Association for the Advancement of Science.
2007 Annual progress report synopsis of the Center for Structures of Membrane Proteins.
Robert M. Stroud, Senyon Choe, James Holton, H. Ronald Kaback, Witek Kwiatkowski, Daniel L. Minor, Roland Riek, Andrej Sali, Henning Stahlberg, and William Harries
Journal of structural and functional genomics, (2009) Berlin: Springer.
Exact distances and internal dynamics of perdeuterated ubiquitin from NOE buildups.
Beat Vögeli, Takuya F. Segawa, Dominik Leitz, Alexander Sobol, Alexandra Choutko, Daniel Trzesniak, Wilfred F. van Gunsteren, and Roland Riek
Journal of the American Chemical Society, (2009) Washington, DC: American Chemical Society.
Correlated dynamics between protein HN and HC bonds observed by NMR cross relaxation.
Beat Vögeli, and Lishan Yao
Journal of the American Chemical Society, (2009) Washington, DC: American Chemical Society.
Solid-state NMR spectroscopy reveals that E. coli inclusion bodies of HET-s(218-289) are amyloids.
Christian Wasmer, Laura Benkemoun, Raimon Sabaté, Michel O. Steinmetz, Bénédicte Coulary-Salin, Lei Wang, Roland Riek, Sven J. Saupe, and Beat H. Meier
Angewandte Chemie. International edition in English, (2009) Weinheim: Wiley.

2008

Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity.
Judit Erchegyi, Christy Rani R. Grace, Manoj Samant, Renzo Cescato, Veronique Piccand, Roland Riek, Jean Claude Reubi, and Jean E. Rivier
Journal of medicinal chemistry, (2008) Washington, DC: American Chemical Society.
Three-dimensional consensus structure of sst2-selective somatostatin (SRIF) antagonists by NMR.
Christy Rani R. Grace, Judit Erchegyi, Jean Claude Reubi, Jean E. Rivier, and Roland Riek
Biopolymers, (2008) New York: Wiley-Blackwell.
Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity.
Christy Rani R. Grace, Judit Erchegyi, Manoj Samant, Renzo Cescato, Veronique Piccand, Roland Riek, Jean Claude Reubi, and Jean E. Rivier
Journal of medicinal chemistry, (2008) Washington, DC: American Chemical Society.
The metal dependence of pyoverdine interactions with its outer membrane receptor FpvA.
Jason Greenwald, Gabrielle Zeder-Lutz, Agnes Hagege, Herve Celia, and Franc Pattus
Journal of bacteriology, (2008) Washington, D.C.: American Society for Microbiology.
Amyloid as a depot for the formulation of long-acting drugs.
Samir K. Maji, David Schubert, Catherine Rivier, Soon Lee, Jean E. Rivier, and Roland Riek
PLoS biology, (2008) Lawrence, KS: Public Library of Science.
The type III secretion chaperone SycE promotes a localized disorder-to-order transition in the natively unfolded effector YopE.
Loren Rodgers, Alicia Gamez, Roland Riek, and Partho Ghosh
The journal of biological chemistry, (2008) Bethesda, MD: The American Society for Biochemistry and Molecular Biology.
The fold of alpha-synuclein fibrils.
Marcal Vilar, Hui-Ting Chou, Thorsten Luehrs, Samir K. Maji, Dominique Riek-Loher, Rene Verel, Gerard Manning, Henning Stahlberg, and Roland Riek
Proceedings of the National Academy of Sciences of the United States of America, (2008) Washington, D.C.: National Academy of Sciences.
Bacterial inclusion bodies contain amyloid-like structure.
Lei Wang, Samir K. Maji, Michael R. Sawaya, David Eisenberg, and Roland Riek
PLoS biology, (2008) Lawrence, KS: Public Library of Science.
Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core.
Christian Wasmer, Adam Lange, Hélène Van Melckebeke, Ansgar B. Siemer, Roland Riek, and Beat H. Meier
SCIENCE, (2008) Washington DC, USA: American Association for the Advancement of Science.
Amyloid fibrils of the HET-s(218-289) prion form a β solenoid with a triangular hydrophobic core.
Christian Wasmer, Adam Lange, Hélène Van Melckebeke, Ansgar B. Siemer, Roland Riek, and Beat H. Meier
Science, (2008) Washington, D.C.: American Association for the Advancement of Science.
Infectious and noninfectious amyloids of the HET-s(218-289) prion have different NMR spectra.
Christian Wasmer, Alice Soragni, Raimon Sabate, Adam Lange, Roland Riek, and Beat H. Meier
Angewandte Chemie. International edition, (2008) Weinheim: Wiley-VCH.
Infectious and Noninfectious Amyloids of the HET-s(218-289) Prion Have Different NMR Spectra.
Christian Wasmer, Alice Soragni, Raimon Sabaté, Adam Lange, Roland Riek, and Beat H. Meier
Angewandte Chemie. International edition : a journal of the Gesellschaft deutscher Chemiker, (2008) Wiley-VCH: Weinheim.

2007

Conformational dynamics of the KcsA potassium channel governs gating properties.
Kent A. Baker, Christos Tzitzilonis, Witek Kwiatkowski, Senyon Choe, and Roland Riek
Nature structural & molecular biology, (2007) New York, N.Y.: Nature Publ. Group.
Common and Divergent Structural Features of a Series of Corticotropin Releasing Factor-Related Peptides.
Christy R.R. Grace, Marilyn H. Perrin, Jeffrey P. Cantle, Wylie W. Vale, Jean E. Rivier, and Roland Riek
Journal of the American Chemical Society, (2007) Washington, DC: American Chemical Society.
Astressin-amide and astressin-acid are structurally different in dimethylsulfoxide.
Christy Rani R. Grace, Laura Cervini, Jozsef Gulyas, Jean Rivier, and Roland Riek
Biopolymers : original research on biomolecules, (2007) New York: Wiley-Blackwell.
Common and Divergent Structural Features of a Series of Corticotropin Releasing Factor-Related Peptides.
Christy Rani R. Grace, Marilyn H. Perrin, Jeffrey P. Cantle, Wylie W. Vale, Jean E. Rivier, and Roland Riek
Journal of the American Chemical Society, (2007) Washington, DC: American Chemical Society.
NMR spectroscopic and analytical ultracentrifuge analysis of membrane protein detergent complexes.
Innokentiy Maslennikov, Georgia Kefala, Casey Johnson, Roland Riek, Senyon Choe, and Witek Kwiatkowski
BMC structural biology, (2007) Unknown: BioMed Central.
Distinct Structural and Functional Roles of Conserved Residues in the First Extracellular Domain of Receptors for Corticotropin-releasing Factor and Related G-protein-coupled Receptors.
Marilyn H. Perrin, Christy R.R. Grace, Michael R. Digruccio, Wolfgang H. Fischer, Samir K. Maji, Jeffrey P. Cantle, Sean Smith, Gerard Manning, Wylie W. Vale, and Roland Riek
Journal of the American Chemical Society, (2007) Washington, DC: American Chemical Society.

2006

C-13, N-15 resonance assignment of parts of the HET-s prion protein in its amyloid form.
Ansgar B. Siemer, Christiane Ritter, Michel O. Steinmetz, Matthias Ernst, Roland Riek, and Beat H. Meier
Journal of biomolecular NMR, (2006) Berlin: Springer.
Observation of highly flexible residues in amyloid fibrils of the HET-s prion.
Ansgar B. Siemer, Alexandre A. Arnold, Christiane Ritter, Thomas Westfeld, Matthias Ernst, Roland Riek, and Beat H. Meier
Journal of the American Chemical Society, (2006) Washington, DC: American Chemical Society.

2005

Correlation of structural elements and infectivity of the HET-s prion.
Christiane Ritter, Marie-Lise Maddelein, Ansgar B. Siemer, Thorsten Lührs, Matthias Ernst, Beat H. Meier, Sven J. Saupe, and Roland Riek
Nature, (2005) London: Nature Publ. Group.
Side-chain H and C resonance assignment in protonated/partially deuterated proteins using an improved 3D13C-detected HCC–TOCSY.
Kaifeng Hu, Beat Vögeli, and Konstantin Pervushin
Journal of magnetic resonance, (2005) Amsterdam: Elsevier.
Detection of C ' C-alpha correlations in proteins using a new time- and sensitivity-optimal experiment.
Donghan Lee, Beat Vögeli, and Konstantin Pervushin
Journal of biomolecular NMR, (2005) Berlin: Springer.
Measuring 1H–1H and 1H–13C RDCs in methyl groups. Example of pulse sequences with numerically optimized coherence transfer schemes.
Konstantin Pervushin, Beat Vögeli, Tim N. Heinz, and Philippe H. Hünenberger
Journal of magnetic resonance, (2005) Amsterdam: Elsevier.
High-resolution solid-state NMR spectroscopy of the prion protein HET-s in its amyloid conformation.
Ansgar B. Siemer, Christiane Ritter, Matthias Ernst, Roland Riek, and Beat H. Meier
Angewandte Chemie. International edition in English, (2005) Weinheim: Wiley.
Simultaneous H-1- or H-2-, N-15- and multiple-band-selective C-13-decoupling during acquisition in C-13-detected experiments with proteins and oligonucleotides.
Beat Vögeli, Helena Kovacs, and Konstantin Pervushin
Journal of biomolecular NMR, (2005) Berlin: Springer.

2004

Measurements of side-chain C-13-C-13 residual dipolar couplings in uniformly deuterated proteins.
Beat Vögeli, Helena Kovacs, and Konstantin Pervushin
Journal of the American Chemical Society, (2004) Washington, DC: American Chemical Society.
An enzymatic molten globule. Efficient coupling of folding and catalysis.
Katherina Vamvaca, Beat Vögeli, Peter Kast, Konstantin Pervushin, and Donald Hilvert
Proceedings of the National Academy of Sciences of the United States of America, (2004) Washington, D.C.: National Academy of Sciences.

2003

Observation of individual transitions in magnetically equivalent spin systems.
Konstantin Pervushin, and Beat Vögeli
Journal of the American Chemical Society, (2003) Washington, DC: American Chemical Society.
NMR structure of the human doppel protein.
Thorsten Lührs, Roland Riek, Peter Güntert, and Kurt Wüthrich
Journal of molecular biology, (2003) Amsterdam: Elsevier.
TROSY: Transverse Relaxation-Optimized Spectroscopy.
Roland Riek
In BioNMR in drug research, 227-241. (2003) Weinheim: Wiley-VCH.

2002

TROSY-NMR reveals interaction between ERp57 and the tip of the calretiuclin P-domain.
Eva-Maria Frickel, Roland Riek, Ilian Jelesarov, Ari Helenius, Kurt Wüthrich, and Lars Ellgaard
Proceedings of the National Academy of Sciences of the United States of America : PNAS, (2002) Washington, D.C.: National Academy of Sciences.
Solution NMR techniques for large molecular and supramolecular structures.
Roland Riek, Jocelyne Fiaux, Eric B. Bertlesen, Arthur L. Horwich, and Kurt Wüthrich
Journal of the American Chemical Society, (2002) Washington, DC: American Chemical Society.

2001

NMR studies in aqueous solution fail to identify significant conformational differences between the monomeric forms of two Alzheimer peptides with widely different plaque-competence, Aβ(1–40)ox and Aβ(1–42)ox.
Roland Riek, Peter Güntert, Heinz Dobeli, Beat Wipf, and Kurt Wüthrich
European Journal of Biochemistry, (2001) Oxford: Blackwell.
Enhancement of the steady-state magnetization in TROSY experiments.
Roland Riek
Journal of biomolecular NMR, (2001) Berlin: Springer.

2000

NMR solution structure of the human prion protein.
Ralph Zahn, Aizhuo Liu, Thorsten Lührs, Roland Riek, Christine von Schroetter, Francisco López García, Martin Billeter, Luigi Calzolai, Gerhard Wider, and Kurt Wüthrich
Proceedings of the National Academy of Sciences of the United States of America, (2000) Washington, DC: National Academy of Sciences.
TROSY and CRINEPT: NMR with large molecular and supramolecular structures in solution.
Roland Riek, Konstantin Pervushin, and Kurt Wüthrich
Trends in Biochemical Sciences, (2000) Amsterdam: Elsevier.
NMR experiments for resonance assignments of 13C, 15N doubly-labeled flexible polypeptides: application to the human prion protein hPrP(23-230).
Aizhuo Liu, Roland Riek, Gerhard Wider, Christine von Schroetter, Ralph Zahn, and Kurt Wüthrich
Journal of biomolecular NMR, (2000) Berlin: Springer.
Determination of h2JNN and h1JHN coupling constants across Watson–Crick base pairs in the Antennapedia homeodomain–DNA complex using TROSY.
Konstantin Pervushin, César Fernández, Roland Riek, Akira Ono, Masatsune Kainosho, and Kurt Wüthrich
Journal of biomolecular NMR, (2000) Berlin: Springer.

1999

Peptides and proteins in neurodegenerative disease: helix propensity of a polypeptide containing helix 1 of the mouse prion protein studied by NMR and CD spectroscopy.
Aizhuo Liu, Roland Riek, Ralph Zahn, Simone Hornemann, Rudi Glockshuber, and Kurt Wüthrich
Peptides, (1999) Amsterdam: Elsevier.

1998

Prion protein NMR structure and familial human spongiform encephalopathies.
Roland Riek, Gerhard Wider, Martin Billeter, Simone Hornemann, Rudi Glockshuber, and Kurt Wüthrich
Proceedings of the National Academy of Sciences of the United States of America, (1998) Washington, DC: National Academy of Sciences.
Prion protein structural features indicate possible relations to signal peptidases.
Rudi Glockshuber, Simone Hornemann, Martin Billeter, Roland Riek, Gerhard Wider, and Kurt Wüthrich
FEBS Letters, (1998) Amsterdam: Elsevier.

1997

Prion (PrPSc)-specific epitope defined by a monoclonal antibody.
Carsten Korth, Beat Stierli, Peter Streit, Markus Moser, Olivier Schaller, Roland Fischer, Walter Schulz-Schaeffer, Hans Kretzschmar, Alex Raeber, Ueli Braun, Felix Ehrensperger, Simone Hornemann, Rudi Glockshuber, Roland Riek, Martin Billeter, Kurt Wüthrich, and Bruno Oesch
Nature, (1997) London: Nature Publishing Group.
Recombinant full-length murine prion protein, mPrP(23-231): Purification and spectroscopic characterization.
Simone Hornemann, Carsten Korth, Bruno Oesch, Roland Riek, Gerhard Wider, Kurt Wüthrich, and Rudi Glockshuber
FEBS Letters, (1997) Amsterdam: Elsevier.
NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).
Roland Riek, Simone Hornemann, Gerhard Wider, Rudi Glockshuber, and Kurt Wüthrich
FEBS Letters, (1997) Amsterdam: Elsevier.
Prion protein NMR structure and species barrier for prion diseases.
Martin Billeter, Roland Riek, Gerhard Wider, Simone Hornemann, Rudi Glockshuber, and Kurt Wüthrich
Proceedings of the National Academy of Sciences of the United States of America, (1997) Washington, DC: National Academy of Sciences.
Three-dimensional NMR structure of a self-folding domain of the prion protein PrP(121-231).
Rudi Glockshuber, Simone Hornemann, Roland Riek, Gerhard Wider, Martin Billeter, and Kurt Wüthrich
Trends in Biochemical Sciences, (1997) Amsterdam: Elsevier.

1996

Diffusion filters for separation of solvent-protein and protein-protein nuclear overhauser effects (HYDRA).
Gerhard Wider, Roland Riek, and Kurt Wüthrich
Journal of the American Chemical Society, (1996) Washington, DC: American Chemical Society.
NMR structure of the mouse prion protein domain PrP(121-231).
Roland Riek, Simone Hornemann, Gerhard Wider, Martin Billeter, Rudi Glockshuber, and Kurt Wüthrich
Nature, (1996) London: Nature Publ. Group.
 
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